Table 4.
Effects of OA on body weight and biochemical parameters in aged female rats.
| NCD | HCD | NCD + OA | |
|---|---|---|---|
| Body weight | |||
| Weight change, % | −1.3 ± 0.4 | −0.4 ± 0.7 | 0.2 ± 1.6 |
| Serum chemistry | |||
| s-Ca, mg/dL | 11.5 ± 0.4 | 11.5 ± 0.2 | 11.9 ± 0.5 |
| s-P,mg/dL | 5.2 ± 0.4 | 5.9 ± 0.2 | 4.9 ± 0.8 |
| s-1,25D, pg/mL | 17.5 ± 2.5 | 3.5 ± 0.7 *** | 13.4 ± 2.9 |
| s-PTH, pg/mL | 213.8 ± 40.9 | 229.2 ± 49.4 | 138.2 ± 58.0 |
| Urine chemistry | |||
| u-Ca/Cr, mg/mg | 0.30 ± 0.05 | 0.38 ± 0.04 | 0.16 ± 0.03 * |
| u-P/Cr, mg/mg | 2.65 ± 0.43 | 0.12 ± 0.07 *** | 2.11 ± 0.24 |
| Bone calcium content | |||
| Bone ash weight, mg | 306.1 ± 8.5 | 351.6 ± 6.1 ** | 318.2 ± 8.0 |
| Ca/Ash bone, μg/mg | 391.8 ± 2.2 | 403.1 ± 3.6 * | 402.8 ± 3.3 * |
Thirteen-month-old female rats were fed with a high calcium diet (HCD, 1.2% calcium, 0.65% phosphorous) or a normal calcium diet (NCD, 0.6% calcium, 0.65% phosphorous) and orally administrated with OA (25 mg/kg/day) or its vehicle treatment for 12 weeks. Body weight is presented as percentage of change from baseline to 12 weeks. 1,25D, 1,25(OH)2D3; s, serum; u, urine; Ca, calcium; P, phosphorus; Cr, creatinine. Urinary calcium and phosphorus levels are expressed as urinary calcium or phosphorus to creatinine ratio. Data is presented as mean ± SEM and analyzed by one-way ANOVA followed by Tukey’s multiple comparison tests. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. NCD.