Table 5.
Effects of OA on Ca balance in aged female rats.
| NCD | HCD | NCD + OA | |
|---|---|---|---|
| Ca intake, mg/day | 92.4 ± 3.9 | 182.1 ± 11.2 | 94.2 ± 4.7 |
| Urine Ca, mg/day | 1.8 ± 0.7 | 5.7 ± 0.6 *** | 1.4 ± 0.2 |
| Fecal Ca, mg/day | 80.2 ± 5.6 | 158.1 ± 19.4 ** | 68.5 ± 5.0 |
| Ca absorption rate, % | 11.2 ± 4.7 | 12.2 ± 10.8 | 23.9 ± 5.9 |
| Net Ca balance, mg/day | 12.3 ± 2.2 | 26.7 ± 4.9 * | 24.9 ± 3.0 * |
Thirteen-month-old female rats were fed with a high calcium diet (HCD, 1.2% calcium, 0.65% phosphorous) or a normal calcium diet (NCD, 0.6% calcium, 0.65% phosphorous) and orally administrated with OA (25 mg/kg/day) or its vehicle treatment for 12 weeks. Ca absorption rate (%) = (Ca intake − fecal Ca)/Ca intake × 100; Net Ca balance = Ca intake − (urinary Ca − fecal Ca). Data is presented as mean ± SEM and analyzed by one-way ANOVA followed by Tukey’s multiple comparison tests. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. NCD.