Table 2.

Signaling pathway enrichment analyses of down- and upregulated DEPs.

Pathway ID	Name	Count	P value
Upregulated
ko04810	Regulation of actin cytoskeleton	6	9.37E − 04
ko05410	Hypertrophic cardiomyopathy (HCM)	3	2.28E − 03
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	3	2.28E − 03
ko04512	ECM-receptor interaction	3	2.28E − 03
ko05414	Dilated cardiomyopathy	3	2.28E − 03
ko05200	Pathways in cancer	6	2.63E − 03
ko05205	Proteoglycans in cancer	5	2.94E − 03
ko04151	PI3K-Akt signaling pathway	5	3.30E − 03
ko04380	Osteoclast differentiation	3	6.79E − 03
ko05032	Morphine addiction	2	6.81E − 03
ko04640	Hematopoietic cell lineage	2	6.81E − 03
ko04919	Thyroid hormone signaling pathway	3	9.72E − 03
ko05020	Prion diseases	2	1.01E − 02
ko04727	GABAergic synapse	2	1.20E − 02
ko04728	Dopaminergic synapse	3	1.42E − 02
ko04145	Phagosome	4	1.43E − 02
ko00361	Chlorocyclohexane and chlorobenzene degradation	1	1.46E − 02
ko00364	Fluorobenzoate degradation	1	1.46E − 02
ko00623	Toluene degradation	1	1.46E − 02
ko04510	Focal adhesion	4	1.64E − 02
ko05100	Bacterial invasion of epithelial cells	3	2.07E − 02
ko04723	Retrograde endocannabinoid signaling	2	2.55E − 02
ko04713	Circadian entrainment	2	2.55E − 02
ko04130	SNARE interactions in vesicular transport	2	2.81E − 02
ko05140	Leishmaniasis	2	2.81E − 02
ko04724	Glutamatergic synapse	2	2.81E − 02
ko04115	p53 signaling pathway	2	3.07E − 02
ko04514	Cell adhesion molecules (CAMs)	2	3.07E − 02
ko05133	Pertussis	2	3.63E − 02
ko05222	Small cell lung cancer	2	3.63E − 02
ko04726	Serotonergic synapse	2	3.63E − 02
ko04725	Cholinergic synapse	2	3.63E − 02
ko04211	Longevity regulating pathway, mammal	2	3.92E − 02
ko05134	Legionellosis	2	4.22E − 02
Downregulated
ko03010	Ribosome	13	2.02E − 07
ko03008	Ribosome biogenesis in eukaryotes	3	3.27E − 02
ko03013	RNA transport	5	4.52E − 02