Table 1.

The classification of proto-oncogenes with tumor-suppressor function (POTSF)

Classification	POTSF genes
Transcription factors	BRCA1, CAMTA1, CBFA2T3, CDX2, CREB3L1, CREBBP, DDB2, DNMT1, DNMT3A, ETV6, EZH2, FOXA1, FOXL2, FOXO1, FOXO3, FOXO4, FOXP1, FUS, IRF4, KLF4, KLF5, NCOA4, NOTCH1, NOTCH2, NOTCH3, NPM1, NR4A3, PAX5, PML, PPARG, RB1, RUNX1, SMAD4, STAT3, TCF3, TCF7L2, TP53, TP63, TRIM24, WT, ZBTB16
Kinases	BCR, CHEK2, EPHA1, EPHA3, EPHB4, FLT3, MAP2K4, MAP3K4, MST1R, NTRK3, PRKAR1A, PRKCB, SYK
Others	ARHGEF12, BCL10, BRCA2, CBL, CDC73, CDH11, CDKN1B, DCC, DDX3 × , DICER1, FAS, FAT1, GPC3, IDH1, IKZF2, LIFR, NF2, NUP98, PHF6, PTPN1, PTPN11, RHOA, RHOB, SH2B3, SLC9A3R1, SOCS1, SPOP, SUZ12, WHSC1L1