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. 2018 Mar 15;19:77. doi: 10.1186/s12859-018-2087-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Image artifact removal applied to all images from BBBC021 dataset of MCF-7 cells [12]. Example of a contrast adjusted (a) and unadjusted (b) original image with noise artifact. The artifact consists of bright pixels oriented along 7 evenly spaced parallel lines with slope of ~ 0.1 (the arrows indicate one such line). The same image, with artifact removal applied as described in main text, shown with contrast adjusted (c) and unadjusted (d). Scale bar is 10 μm or 30 pixels. Artifact is best viewed in digital form