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The effects of spermidine on aging and cardiovascular health. (a) Aging increases the risk of cardiovascular disease, which manifests as increased hypertrophy and decreased diastolic function. (b) Eisenberg et al.1 show that dietary supplementation of mice with spermidine decreases the risk of CVD and death upon aging via an increase in autophagy, which results in increased cardiomyocyte fitness.
