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. 2018 Mar 14;20:44. doi: 10.1186/s13075-018-1540-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Correlation of immunoglobulin G (IgG) hypogalactosylation with disease activity in seropositive and seronegative rheumatoid arthritis (RA). Relationship between IgG agalactosylated immunoglobulin G/monogalactosylated immunoglobulin G (G0/G1) ratio and activity markers ((a) Disease Activity Score in 28 joints [DAS28], (b) C-reactive protein [CRP], and (c) erythrocyte sedimentation rate [ESR]) in RA, stratified by seropositive (sero+ anticitrullinated protein antibody [ACPA] and/or sero+ rheumatoid factor [RF]) and seronegative (sero− ACPA and sero− RF) status. Results of regression analyses and 95% CIs are given, as well as p values for heterogeneity. Sex is indicated by upright triangles (female) and inverted triangles (male). In regard to multiple testing, a Bonferroni-corrected p value of p < 0.0042 should be applied