Level of evidence (LOE) |
Ia |
Meta-analysis of randomized controlled trials |
Ib |
At least one randomized controlled trial |
IIa |
At least one well-designed controlled study without randomization |
IIb |
At least one other type of well-designed quasi-experimental study |
III |
Descriptive studies such as comparative studies, correlation studies and case studies |
IV |
Expert committee reports, clinical experiences and opinions of respected authorities |
|
Grade of recommendation |
A (LOE Ia and Ib) |
Recommendation should be followed |
B (LOE IIa, IIb, and III) |
Recommendation being reasonable or recommended to do |
C (LOE IV) |
Recommendation being considered to do |
Good clinical practice (GCP) |
Consensus opinion of the guideline development group |