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. 2017 Dec 8;217(5):721–730. doi: 10.1093/infdis/jix639

Figure 5.

Figure 5.

MG1 infection of memory CD4+ T cells from combination antiretroviral therapy recipients with virologically suppressed human immunodeficiency virus type 1 (HIV-1) infection results in a reduction in the size of the inducible reservoir. A, Experimental design for the MG1 infection of memory CD4+ T cells isolated from HIV-1–infected individuals. B, Cell-associated total HIV-1 DNA level 48 hours after MG1 infection in each HIV-1–infected individual, relative to MG1-uninfected controls (n = 14). *P = .0011 by the paired t test. C, Relative HIV-1 gag level in supernatant after 21 days of viral outgrowth (n = 4). *P < .001 by 1-way analysis of variance (ANOVA), and P < .05 by the Dunnett multiple comparison test; †P = .0354 by paired t test for comparison of the multiplicity of infection (MOI) 10 group to the 10 UV group. D, Cell-associated total HIV-1 DNA level 48 hours after MG1 infection, relative to MG1-uninfected controls (n = 13). *P = .0035 by 1-way ANOVA on ranks, and P < .05 by the Dunn multiple comparison test. Data represent mean values ± standard errors of the mean; n values represent separate biological replicates. Individual HIV-infected donors are defined by color in panels C and D. ELISA, enzyme-linked immunosorbent assay; GFP, green fluorescent protein; NS, not significant; PCR, polymerase chain reaction.