Table 2.
Univariate and Multivariable Analysis of Patient and Viral Factors for C-Case Dengue Virus Infections With Positive and Negative Annual Sample Test Results
| Multivariable analysisa | ||||||
|---|---|---|---|---|---|---|
| Patient and Viral Factors | Annual sample positive | Annual sample negative | Univariate P value |
Log odds (Ln) | Standard error | P value |
| Number (%) | 53 (100) | 58 (100) | ||||
| Male, no. (%)b | 27 (50.9) | 29 (50.0) | 1.00 | |||
| Age, mean (SD) | 7.7 (3.0) | 6.0 (2.8) | .002 | … | … | … |
| Day of fever, mean (SD) | 1.9 (0.9) | 2.0 (1.1) | .51 | … | … | … |
| Day postsymptom onset, mean (SD) | 2.4 (1.3) | 2.9 (1.8) | .09 | −0.096 | 0.284 | .74 |
| Viral load,c geometric mean (SD) | 7.6 (1.5) | 4.5 (1.6) | <.001 | 1.164d | 0.201 | <.001 |
| Primary infection, no. (%) | 33 (62.3) | 39 (67.2) | .69 | … | … | … |
| First fever to annual sample, mean days (SD)e | 190.9 (55.3) | 226.6 (92.5) | .02 | … | … | … |
| DENV serotype, no. (%)f | ||||||
| DENV-1 | 13 (24.5) | 14 (24.1) | 1.00 | Reference | ||
| DENV-2 | 6 (11.3) | 31 (53.4) | <.001 | 1.848 | 1.269 | .15 |
| DENV-3 | 34 (64.2) | 13 (22.4) | <.001 | 2.457 | 1.088 | .03 |
Abbreviations: DENV, dengue virus; SD, standard deviation.
aVariables indicated … were not included in the best-fit model.
bSex was not included in multivariable analysis.
cViral load is expressed as log10 copies/mL serum.
dOdds of a positive annual sample increase by e1.164x, where “x” represents each 1.0 log10 copies/mL increase in viral load (ie, the odds of having a positive annual sample with a viral load of 7.0 vs 4.0 log10 copies/mL is e3.492, or 32.85)
eCalculated as the time between the date of a patient’s first fever and collection of the postinfection annual sample.
fDENV-1 was used as the reference serotype in multivariable analysis.