Figure 4.

Posaconazole-loaded dHL-60 cell mediated inhibition of Aspergillus fumigatus. Differentiated HL-60 (dHL-60) cells exposed to the indicated posaconazole concentrations were cocultured with pregrown A. fumigatus hyphae for 12 hours. Bars represent mean fungal metabolic activity normalized to that of untreated fungi, as measured by the XTT assay. Error bars indicate standard errors of the mean (SEM) from at least 4 independent experiments. *P < .02 and **P < .005 compared to the same multiplicity of infection (MOI) at different posaconazole concentrations, using a paired t test.