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. 2018 Jan 20;217(6):916–925. doi: 10.1093/infdis/jix644

Figure 1.

Figure 1.

Early intramuscular transgene expression kinetics of 5 different adeno-associated virus (AAV) capsids. Albino C57BL/6 mice (n = 4 per group) were injected intramuscularly with 1 × 1011 vector genomes of an AAV vector expressing firefly luciferase (Luc) packaged with either AAV6, AAV6.2FF, AAV8, AAV9, or AAV-DJ capsid. A, In vivo luciferase images were obtained 0, 1, 3, 7, and 14 days after AAV administration to demonstrate vector distribution. B and C, Relative photon emission produced by luciferase from the muscle exclusively (quantified from the lateral view; B) or the muscle plus the liver (quantification of the ventral view; C) of each serotype of AAV was quantified at various time points from 1 to 112 days after injection. Multiple t tests were used to compare each time point. *P < .05 for comparison of AAV6.2FF to all other capsids; #P < .05 for comparison of AAV6.2FF to AAV8, AAV9, and AAV-DJ; †P < .05 for comparison of AAV6.2FF to AAV8 and AAV9; and §P < .05 for comparison of AAV6.2FF to AAV8.