Table 1.
Results of Mouse-Adapted Ebola Virus (MA-EBOV) Challenge 140 Days Following Intramuscular Delivery of Adeno-Associated Virus (AAV) Monoclonal Antibody Vectors
| AAV Vector, Mouse | ELISA OD Before Challengea | Outcome |
|---|---|---|
| AAV-2G4 | ||
| 1 | 2.8 | Survived |
| 2 | 2.2 | Survived |
| 3 | 2.1 | Survived |
| 4 | 2.8 | Survived |
| AAV-5D2 | ||
| 1 | 1.5 | Survived |
| 2 | 2.0 | Survived |
| 3 | 2.4 | Survived |
| 4 | 2.3 | Survived |
| AAV-2G4 + AAV-5D2 | ||
| 1 | 2.1 | Survived |
| 2 | 2.5 | Survived |
| 3 | 2.9 | Survived |
| 4 | 0.8 | Survived |
Abbreviation: ELISA, enzyme-linked immunosorbent assay.
aSerum specimens were collected from mice 14 days before intraperitoneal challenge with 1000 times the lethal dose (50%) of MA-EBOV.