Figure 6.

Δ346 mutant is attenuated in a mouse model of Zika virus disease. A–C, Eleven-week old type I/II interferon receptor knockout mice were infected with 10³ C6/36 focus forming units via footpad injection and monitored for (A) survival (log-rank test, *P < .05) and (B) weight loss (mean ± standard error of the mean [SEM]) (two-tailed Student t test, *P < .05). C, Mice were harvested at day 6, and serum and brain were collected and titered on C6/36 cells (mean ± SEM). Virus below limits of detection are plotted on x axis. WT, wild type.