Table 2.
Herpesvirus Infections and LTL in Whitehall Heart Scan Study (N = 400)
| Whitehall Heart Scan Study | LTL (T/S Ratio (Follow-up) | |||
|---|---|---|---|---|
| Model 1a | Model 2a | |||
| β (SE) | P Value | β (SE) | P Value | |
| Pathogen present | ||||
| CMV | −0.061 (0.014) | <.001 | −0.059 (0.014) | <.001 |
| HSV-1 | −0.049 (0.016) | .002 | −0.047 (0.017) | <.006 |
| HHV-6 | −0.033 (0.015) | .02 | −0.027 (0.014) | .06 |
| EBV | 0.001 (0.015) | .95 | 0.009 (0.015) | .52 |
| Covariate | ||||
| Age | … | … | −0.005 (0.001) | <.001 |
| Female sex | … | … | 0.062 (0.014) | <.001 |
| LTL at baseline | … | … | 0.523 (0.093) | <.001 |
| Current vs never smoking | … | … | −0.007 (0.031) | .83 |
| Obese vs normal weight | … | … | −0.021 (0.021) | .31 |
Abbreviations: CMV, cytomegalovirus; EBV, Epstein-Barr virus; HHV, human herpesvirus; HSV, herpes simplex virus; SE, standard error; LTL, leukocyte telomere length; T/S ratio, telomere to single copy gene ratio.
aAll models were adjusted for age, sex, smoking, employment grade, categorical body mass index, and baseline LTL. Model 1 shows coefficients for separate regressions with individual infections. In model 2, coefficients are mutually adjusted for the other infections.