Table 1.

Motor Impairment Scoring

Score	Description a
0	No impairment
1	Mild impairment, ataxia or decreased movement present, toe/ knuckle walking
2	Moderate impairment, profound ataxia, limited movement of limb
3	Severe impairment, no movement of limb, limb is non–weight bearing

^aMice were observed on a flat surface for several minutes. The final score for each mouse was calculated by adding the scores for each limb.