Table 3.

Characteristics of the Selected Significant Coexpressed Network Modules of Severe and Nonsevere Group in NP Swabs and Blood

Group	Sample Type	WGCNA Module Selected	Correlation of Gene Expression With Phase of Infections and DOI	Correlation of Gene Expression With Severity and RSV Load	Top 3 GO- Functional Enrichment Pathway
Severe	NP	Turquoise	Negative	Positive	Immune response, immune system process, defense response
		Brown	Negative	Positive	Immune response, immune system process, defense response, innate immune response
		Dark-turquoise	Negative	Positive	Immune system process, immune response, T-cell aggregation
		Green	Positive	Negative	Regulation of signal transduction, enzyme- linked receptor protein signaling pathway
	Blood	Floral-white	Negative	Positive	Response to type I interferon, cellular response to type I interferon, innate immune response
		Black	Negative	Positive	Immune system process, response to stress, defense response
		Light-pink4	Negative	Positive	Vesicle-mediated transport, Toll-like receptor 4 signaling pathway, endomembrane system organization
Nonsevere	NP	Blue	Positive	Negative	Cilium morphogenesis, cilium assembly, cilium organization
		Yellow	Positive	Negative	Oxoacid metabolic process, carboxylic acid metabolic process, organic acid metabolic process
		Royal-blue	Positive	Negative	Mitotic cell cycle, cell cycle
	Blood	Turquoise	Positive	Negative	Heme metabolic process, heme biosynthesis process, locomotion
		Antique-white4	Positive	Negative	Endothelial cell-cell adhesion, leukotriene metabolic process

Abbreviations: DOI, day of illness; GO, gene ontology; NP, nasopharyngeal swabs; RSV, respiratory syncytial virus; WGCNA, weighted gene coexpression network analysis.