Figure 3.

Anti-EhMIF antibody treatment reduces E. histolytica–induced inflammation. A, Immunohistochemical stain showing EhMIF protein expression (brown) and interaction with host during infection. Scale bars, 50μm. B-D, Mice treated with anti-EhMIF antibodies had reduced intestinal tissue levels of CXCL1 chemokine, neutrophil infiltration, and MMP-3. Data represent mean and SD (n = 5 mice per group).

*P < .05; **P < .01.

Abbreviations: CXCL1, C-X-C motif chemokine ligand 1; EhMIF, Entamoeba histolytica macrophage migration inhibitory factor; MMP-3, matrix metalloproteinase 3; ns, not significant.