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. 2017 Sep 14;216(10):1318–1327. doi: 10.1093/infdis/jix472

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© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Evolution and emergence of the ST618 and ST3081 serotype 1 isolates in The Gambia. A, Distribution of accessory genes and mutations in the 380 position of the pneumolysin gene, specific to ST618 and ST3081 serotype isolates in Gambia. MLST, multilocus sequence type; SNPs, single-nucleotide polymorphisms; ST, sequence type. B, C, Nucleotide substitution (mutation) rates and potential years of emergence of the ST3081 (B) and ST618 (C) serotype 1 clones. TMRCA, time to the most common ancestor.