Table 1.

Clinical Features of ZIKV Compared With Other Arboviruses

Flavivirus						Alphavirus
	ZIKV	DENV	WNV	YFV	JEV	CHIKV
Nonvector borne transmission
Materno fetal	Yes	Yes	No	Yesa	No	Yes
Sexual	Yes	No	No	No	No	No
Transfusion	Yes	Yes	Yes	Yesa	No	No
Main complication in newborn
Microcephaly	Yes	No	No	No	No	No
Other CNS malformation	Yes	No	No	No	No	No
Main complications in infants and adults
Bleeding	No	Yes	Yes	Yes	No	Yes
Plasma leakage	No	Yes	No	Yes	No	No
Severe organ involvement	No	Yes	Yes	Yes	No	No
Chronic arthralgia	No	No	No	No	No	Yes
Main complications in adults
Guillain-Barré syndrome	Yes	Yes	Yes	Yesa	Yes	Yes
Meningoencephalitis	Yes	Yes	Yes	Yesa	Yes	Yes
Myelitis	Yes	Yes	No	Yesa	Yes	Yes
Meningitis	No	No	Yes	Yesa	Yes	No
Prevention and treatment
Vaccine	No	Yes	No	Yes	Yes	No
Specific treatment	No	No	No	No	No	No

Abbreviations: CHIKV, chikungunya virus; CNS, central nervous system; DENV, dengue virus; JEV, Japanese encephalitis virus; WNV, West Nile virus; YVF, yellow virus fever; ZIKV, Zika virus.

^aWith yellow fever vaccine virus.