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. 2017 Jul 22;216(6):688–696. doi: 10.1093/infdis/jix352

Figure 3.

Figure 3.

Human bocavirus (HBoV) capsid messenger RNA (mRNA) and DNA load in nasopharyngeal and oropharyngeal swab specimens from children with community-acquired pneumonia (CAP) and controls. A, At approximately 4 × 104 copies/mL, the median HBoV capsid mRNA load in children with CAP was similar to that in controls. B, Median DNA load was approximately 2-fold higher in children with CAP (622 copies/mL) than in controls (375 copies/mL), but this difference was not statistically significant. However, a subset of children with CAP, as well as 2 controls, had HBoV DNA loads of 1 × 106–1 × 109 copies/mL. C, When stratifying HBoV DNA loads by HBoV capsid mRNA positivity, median HBoV DNA loads were 100000–1000000-fold higher in capsid mRNA–positive children with CAP (7.4 × 107 copies/mL) and controls (4.6 × 108 copies/mL) than in capsid mRNA–negative children with CAP (4.8 × 102 copies/mL) and controls (3.7 × 102 copies/mL). Conversely, HBoV DNA loads were similar in capsid mRNA– negative patients and controls and capsid mRNA–positive patients and controls. Children with no HBoV nucleic acid detected are not shown.