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. 2017 Aug 17;216(8):1027–1037. doi: 10.1093/infdis/jix400

Figure 4.

Figure 4.

Pathways and regulators associated with RSV group A and B. A, Pathways associated with respiratory syncytial virus (RSV) group infection. Ingenuity pathway analysis (IPA) was used to identify canonical pathways represented by genes associated with infection by RSV group (A/B) in CD4 lymphocytes. The variables used to generate gene sets for IPA were derived from multivariate analyses (a; n = 68) or univariate analysis (b; n = 53). Ten pathways are shown where Fisher’s exact test P values were <.05 for at least 1 gene list. Genes included in each pathway are listed and are colored red if increased in RSV strain A or green if decreased in strain A and in bold for genes with >1.5-fold changes in expression. B, Regulators associated with RSV group infection. Ingenuity pathway analysis was used to identify upstream regulators associated with infection by RSV group (A/B) using gene sets identified with multivariate (blue; n = 68 genes) or univariate (red; n = 53 genes) analysis. Nine upstream regulators are shown where P values were <.05 for at least 1 gene list. Upstraem regulator targets are listed in red if upregulated and green if downregulated in RSV A strain–infected subjects.