Table 1.
Measures of Invasion Efficiency for PfRh2b Allele Transgenic Strains
| PMR | SI | IE | |
|---|---|---|---|
| Strain (mean, CI) | |||
| 3D7 | 5.72 (4.25, 7.17) | 8.93 (4.48, 13.39) | 49.17 (26.25, 72.08) |
| WT | 4.37 (3.02, 5.72) | 12.70 (7.20, 18.20) | 37.30 (25.50, 49.10) |
| DEL A | 7.21 (3.02, 11.40) | 9.10 (6.32, 11.88) | 48.32 (19.95, 76.69) |
| DEL B | 5.80 (2.45, 9.16) | 12.24 (5.52, 18.97) | 39.69 (12.40, 66.98) |
| 1-way ANOVA | P = .0927 | P = .1023 | P = .3679 |
PMR, SI, and IE are calculated for transgenic parasites and controls. Data shown is from 3 independent experiments. Means and 95% CIs are shown. Overall significance is assessed by 1-way ANOVA.
Abbreviations: ANOVA, analysis of variance; CI, confidence interval; DEL, PfRh2b deletion single crossover parasites; IE, invasion efficiency; PfRh2b, Plasmodium falciparum reticulocyte-binding protein homologue 2b; PMR, parasite multiplication rate; SI, selectivity index; WT, PfRh2b wild-type replacement parasite line (1A).