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. 2016 Aug 5;215(5):813–817. doi: 10.1093/infdis/jiw355

Figure 1.

Figure 1.

Angiopoietin-2 (ANG-2) is expressed around mycobacterial granulomas. A, Detection of ANG-2 expression, pseudo-colored red, in CD68-positive macrophages, pseudo-colored green, by fluorescent immunodetection in a section of human lung from a patient infected with Mycobacterium tuberculosis. The image is representative of 3 examined patient samples infected with M. tuberculosis. B, Detection of ANG-2 expression from the field of view in panel A. C, Detection of zebrafish Ang2 (magenta) by antibody staining around Mycobacterium marinum–tomato granulomas in a Tg(kdrl:egfp) embryo where the blood vessels are marked with enhanced green fluorescent protein expression. D, Detection of zebrafish Ang2 expression from the field of view in panel C. White arrowheads indicate the largest mycobacterial granulomas in each field of view. Scale bars represent 100 µm.