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ΔF508 mice demonstrate an increased mortality rate after infection with Coxsackievirus. ΔF508 mice (dotted lines) and wild-type (wt) littermate controls (solid lines) were infected with Coxsackievirus B3 (CVB3) and monitored for 28 days. A, Wt (n = 10) and ΔF508 (n = 9) mice infected with 104 plaque-forming units (PFU) CVB3/mouse. B, wt (n = 3) and ΔF508 (n = 10) infected with 102 PFU CVB3/mouse. Log-rank (Mantel–Cox) test.
