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. 2017 Oct 16;216(10):1308–1317. doi: 10.1093/infdis/jix474

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© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — ΔF508 mice show a delayed interferon-alpha (IFN-α) response after stimulation with poly(I:C). A, Wild-type (wt; n = 6) and ΔF508 (n = 8) mice were infected with Coxsackievirus B3 (10⁴ plaque-forming units [PFU]/mouse) and serum was drawn on day 2 postinfection. B, Wt (n = 8–14 per time point) and ΔF508 (n = 6–8 per time point) mice were stimulated with poly(I:C) (100 μg/mouse, intraperitoneal) and serum was drawn at 2 hours and 4 hours after stimulation. IFN-α levels in serum from wt mice (black bars) and ΔF508 mice (white bars) from infected mice (A) or mice stimulated with Poly(I:C) (B) were measured using enzyme-linked immunosorbent assay. Data is presented as means ± SD *P < .05, **P < .01, and ***P < .001, two-way analysis of variance with Holm–Sidak’s correction.