Table 1.

Femoral Structural Indices Determined by Micro–Computed Tomography in Control (Sham) and CD4⁺ and CD8⁺ T-Cell–Reconstituted Mice

Index	CD4+ T-Cell–Associated Comparison, Mean ± SD				CD8+ T-Cell–Associated Comparison, Mean ± SD
	Sham Group	Reconstituted Group	Percentage Change	Exact Pa	Sham Group	Reconstituted Group	Percentage Change	Exact Pa
Trabecular
Total volume, mm3	1.27 ± 0.07	1.41 ± 0.06	+11.1	≤.0025	1.26 ± 0.06	1.36 ± 0.09	+7.2	≤.0682
Bone volume, mm3	0.060 ± 0.011	0.026 ± 0.006	−56.7	≤.0001	0.062 ± 0.012	0.028 ± 0.007	−52.7	≤.0001
Bone volume fraction, %	4.75 ± 0.01	1.85 ± 0.41	−61.2	≤.0001	4.88 ± 0.01	2.07 ± 0.42	−54.6	≤.0001
Trabecular thickness, mm	0.041 ± 0.003	0.036 ± 0.005	−11.8	≤.0793	0.041 ± 0.003	0.036 ± 0.005	−12.4	≤.0507
Trabecular number, /mmb	3.20 ± 0.20	2.49 ± 0.12	−22.1	≤.0001	3.22 ± 0.19	2.67 ± 0.12	−16.4	≤.0003
Trabecular separation, mm	0.316 ± 0.022	0.407 ± 0.018	+31.8	≤.0001	0.313 ± 0.021	0.382 ± 0.014	+20.9	≤.0001
Cortical
Cortical area, mm2	0.879 ± 0.049	0.748 ± 0.041	−15.0	≤.0006	0.879 ± 0.049	0.829 ± 0.094	−5.7	≤.2802
Cortical thickness, mm	0.192 ± 0.012	0.159 ± 0.009	−17.5	≤.0003	0.192 ± 0.012	0.180 ± 0.014	−6.4	≤.1320
Total cross- sectional area, mm3	0.497 ± 0.028	0.421 ± 0.024	−15.4	≤.0006	0.497 ± 0.028	0.459 ± 0.036	−7.8	≤.0683
Cortical area fraction, %	176.8 ± 0.4	177.8 ± 0.5	+0.6	≤.0022	176.8 ± 0.4	180.4 ± 8.1	+2.0	≤.3284

Data for 6 mice per group.

^aBy the Student t test.

^bCalculated as the inverse of the mean distance between the mid-axes of the femur.