Figure 1.

A, Distribution of trough piperaquine (PQ) concentrations by gestational week. Dots show measured concentrations. Box plots represent the median and interquartile range. Concentrations below the limit of quantification (BLQ) were excluded from the analysis. B, Visual predictive check of final pharmacokinetic model. Dots represent measured PQ concentrations, the solid line is the observed median, and the dashed lines are the 5th and 95th percentiles of the observed data. Shaded areas represent simulated 5th, 50th, and 95th percentiles with uncertainty. Model fit is adequate if shaded areas from simulated data encompass solid and dashed lines representing the observed data.