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sigK mutants display lower virulence in hamsters. Groups of hamsters were administered clindamycin and then, 16 h later, dosed by intragastric gavage with vegetative cells (106) of Clostridium difficile 630 (wild-type, cotE+) or JP051 (sigK–). Data represented as time from inoculation of C. difficile vegetative cells until time of clinical endpoint combined with heat-resistant spore counts from cecum. Abbreviation: CFU, colony-forming units.
