Table 4.
Changes in Lipid Parameters
| Characteristic | Arm | No. | Mean | (95% CI) | P Value |
|---|---|---|---|---|---|
| Total cholesterol (mmol/L) | Control | 77 | 0.06 | (−.15 to .28) | |
| MVC + 2 N(t)RTIs | 134 | −0.45 | (−.59 to −.31) | <.0001 | |
| Difference | 0.51 | (.26–.76) | |||
| MVC + PI/r | 150 | 0.34 | (.19–.48) | ||
| Difference | −0.27 | (−.53 to −.02) | .0345 | ||
| HDL-c (mmol/L) | Control | 77 | 0.05 | (.00–.11) | |
| MVC + 2 N(t)RTIs | 134 | 0.04 | (−.01 to .08) | ||
| Difference | 0.02 | (−.06 to .09) | .628 | ||
| MVC + PI/r | 150 | 0.10 | (.04–.16) | ||
| Difference | −0.04 | (−.14 to .05) | .3591 | ||
| LDL-c (mmol/L) | Control | 77 | 0.10 | (−.08 to .28) | |
| MVC + 2 N(t)RTIs | 132 | −0.27 | (−.38 to −.16) | ||
| Difference | 0.37 | (.17–.57) | .0002 | ||
| MVC + PI/r | 143 | 0.18 | (.05–.30) | ||
| Difference | −0.07 | (−.29 to .14) | .4871 | ||
| TGs (mmol/L) | Control | 77 | −0.0795 | (−.2816 to .1227) | |
| MVC + 2 N(t)RTIs | 134 | −0.4016 | (−.5418 to −.2615) | ||
| Difference | 0.3222 | (.0835–.5608) | .0084 | ||
| MVC + PI/r | 147 | 0.1146 | (−.1857 to .4148) | ||
| Difference | −0.194 | (−.6326 to .2445) | .3842 |
Abbreviations: CI, confidence interval; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; MVC, maraviroc; N(t)RTI, nucleoside/nucleotide reverse transcriptase inhibitor; PI/r, ritonavir-boosted protease inhibitor; TGs, triglycerides.