Figure 1.

Transcripts enriched by stimulation of primary human nasal epithelial cells with RIG-I ligand SLR14 to mimic viral infection. Primary human nasal epithelial cells (HNEC) were transfected with SLR14 for 1 hour, then incubated for 7 additional hours at 37°C, followed by RNA isolation and transcript analysis by RNAseq. Dots represent transcripts significantly different in control versus SLR14 stimulated HNEC (adjusted P-value of <0.05, log₂ FoldChange >1 or <−1). Labels highlight transcripts examined in this study as potential nasopharyngeal biomarkers of viral respiratory infection. A more extensive list of differentially expressed transcripts can be found in Supplementary Table S1.