Figure 3.

Receiver operator characteristic curve (ROC) analysis of chymase level for patients with dengue. A, ROC analysis graphs are presented for the total patient population. B, ROC analysis for patients who presented <4 days after fever demonstrates excellent early detection of dengue hemorrhagic fever or dengue shock syndrome for patients tested during the acute phase of disease. C, ROC analysis graph of patients who were confirmed to be positive for dengue virus (DENV) infection is similar to that of all patients in panel A. D, For a cutoff of 1.5 ng/mL in the serum chymase level, the sensitivity for all groups ranged between 0.9–1.0, while the specificity averaged around 0.8 for all groups, including various age groups presented in supplementary figure 3. The area under the curve (AUC) is provided for panels A–C.