Table 3.

The association between MRI brain measures and cognitive performance in Type 2 diabetes

	Hippocampal volumea
	Left		Right		Hippocampal asymmetry		Total brain volumea
Cognitive domain	Correlation [95% CI]	p	Correlation [95% CI]	p	Correlation [95% CI]	p	Correlation [95% CI]	p
Power of attention (ms)b	−0.21 [−0.37, −0.05]	.023	−0.30 [−0.47, −0.14]	.001	−0.23 [−0.40, −0.07]	.014	−0.31 [−0.42, −0.18]	.001
Continuity of attention	0 [−0.12, 0.13]	.99	0.01 [−0.13, 0.15]	.91	−0.01 [−0.18, 0.17]	.95	−0.02 [−0.18,0.04]	.82
Quality of episodic memory	0.06 [−0.11, 0.23]	.53	0.21 [0.02, 0.38]	.027	0.26 [0.08, 0.43]	.005	0.18 [−0.00, 0.35]	.054
Quality of working memory	0.06 [−0.10, 0.22]	.52	0.13 [−0.04, 0.31]	.15	0.16 [−0.02, 0.32]	.10	0.18 [0.03, 0.33]	.048
Speed of memory (ms)b	−0.18 [−0.33, −0.02]	.06	−0.23 [−0.37, −0.09]	.014	−0.15 [−0.32, 0.02]	.10	−0.31 [−0.44, −0.16]	.001
Executive function	0.11 [−0.06, 0.27]	.25	0.24 [0.05, 0.40]	.010	0.28 [0.07, 0.49]	.002	0.10 [−0.06, 0.28]	.31
Semantic fluency	0.12 [−0.02, 0.26]	.20	0.20 [0.07, 0.33]	.030	0.21 [0.02, 0.37]	.027	0.18 [0.03, 0.33]	.06
Significant results, controlled for total brain volume:
Quality of episodic memory					0.23 [0.07, 0.40]	.013
Executive function			0.22 [0.02, 0.41]	.017	0.27 [0.04, 0.46]	.004

Partial correlations controlled for sex, age, and estimated FSIQ.

^aAdjusted for intracranial volume.

^bHigher scores indicate poorer performance.