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. 2017 Dec 15;8(1):e00881. doi: 10.1002/brb3.881

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© 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effect of compound‐A on feeding‐relating peptide gene expression in the brain of DIO‐F344 rats. DIO‐F344 rats under ad libitum (Ad lib) conditions were fasted for 16 hr (Fast) and then orally administered with vehicle or compound‐A (30 mg/kg). At 1 hr after dosing, the brain samples were dissected and mRNA level listed in Table 2 was measured. (a–k) The expression levels of Crh (a), Oxt (b), and Avp (c) in the PVH, Pomc (d), Cart (e), Npy (f), and Agrp (g) in ARC, Pmch (h), Hcrt (i), and Cart (j) in the LHA, and Cart (k) mRNA in the NTS were measured via quantitative RT‐PCR. The mRNA expression of each gene was normalized to that of cyclophilin. Results are presented as mean values ± standard deviation (n = 5–6). ^§ p < .05 versus vehicle (Ad lib), *p < .05 versus vehicle (Fast) (Student's t test)