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. 2017 Jun 17;216(4):436–446. doi: 10.1093/infdis/jix291

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© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Volcano plot of the reactive oxygen species–produced oxylipin profiles of combination antiretroviral therapy (cART)/human immunodeficiency virus type 1 (HIV-1)–exposed infants vs control infants. Thirteen metabolites were identified as significantly increased (black rings) in the cART/HIV-1–exposed-infants compared to control infants. Volcano plots visualizes the log₁₀ (Mann–Whitney P value) on the y-axis and the log₂ (fold change [FC]) on the x-axis for each metabolite compared between the cART/HIV-1–exposed infants vs control infants. The dotted lines represent the significance thresholds with FC > 1.25 and FC < 0.75 on the x-axis and P < .05 on the y-axis. Abbreviations: 8-iso-PGF_2α, 8-iso-prostaglandin F_2α; cART, combination antiretroviral therapy; FC, fold change; HDoHE, hydroxyl-docosahexaenoic acid; HEPE, hydroxy-eicosapentaenoic acid; HETE, hydroxy-eicosatetraenoic acid; HIV, human immunodeficiency virus.