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. 2017 Jun 17;216(4):436–446. doi: 10.1093/infdis/jix291

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© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Volcano plot of lipid profiles of combination antiretroviral therapy (cART)/ human immunodeficiency virus type 1 (HIV-1)–exposed infants vs control infants. Overall, 32 triglycerides (black rings) and 2 diacylglycerols (gray rings) were increased with 6 phospholipids (large dark grey circles) having decreased levels in cART/HIV-1–exposed infants compared to control infants. Sphingomyelins (black dots) and phospholipids (small dark grey dot) with P < .05 are also shown. Volcano plots visualizes the log₁₀ (Mann–Whitney P value) on the y-axis and the log₂ (fold change [FC]) on the x-axis for each metabolite compared between the cART/HIV-1–exposed infants vs control infants. The dotted lines represent the significance thresholds with FC > 1.25 and FC < 0.75 on the x-axis and P < .05 on the y-axis.