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. 2017 Jun 17;216(4):436–446. doi: 10.1093/infdis/jix291

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© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Volcano plot of cyclooxygenase, lipoxygenase, and cytochrome P450 oxylipin profiles of combination antiretroviral therapy (cART)/human immunodeficiency virus type 1 (HIV-1)–exposed infants vs control infants. Significantly increased or decreased oxylipins in the cART/HIV-1–exposed-infants compared to the control infants are shown as grey rings. Volcano plots visualizes the log₁₀ (Mann–Whitney P value) on the y-axis and the log₂ (fold change [FC]) on the x-axis for each metabolite compared between the cART/HIV-1–exposed infants vs control infants. The dotted lines represent the significance thresholds with FC > 1.25 and FC < 0.75 on the x-axis and P < .05 on the y-axis. Abbreviations: 20-carboxy-LTB₄, 20-carboxy-leukotriene B₄; cART, combination antiretroviral therapy; DiHDoHE, dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid; DiHETrE, dihydroxy-eicosatrienoic acid; EpDPE, epoxy-docosapentaenoic acid; FC, fold change; HEPE, hydroxy-eicosapentaenoic acid; HIV, human immunodeficiency virus; HOTrE, hydroxy-9Z,11E,15Z-octadecatrienoic acid.