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. 2017 Jun 17;216(4):436–446. doi: 10.1093/infdis/jix291

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© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Pearson correlation networks illustrating the correlation between metabolite classes and classic immunological markers. The correlation network shows the correlations (P < .05) between the measured cytokines and chemokines and the normalized metabolites for reactive oxygen species lipid peroxidation metabolites (A); triglycerides, sphingomyelins, diacylglycerols, cholesteryl esters, and free fatty acids (B); phospholipids and lysophospholipids (C); and enzymatic oxylipins (D) (Supplementary Tables 3–7). Abbreviations: 5-iPGF2α-VI, 5-isoprostane F2α VI; 8-iso-PGF2α, 8-iso-prostaglandin F2α; CE, cholesteryl ester; Cer, ceramides; COX, cyclooxygenase; CYP450, cytochrome P450; DG, diacylglycerol; DiHDoHE, dihydroxydocosahexaenoic acid; DiHETE, dihydroxyeicosatetraenoic acid; DiHETrE, dihydroxyeicosatrienoic acid; DiHODE, dihydroxyoctadecadienoic acid; DiHOME, dihydroxyoctadecenoic acid; EpDPE, epoxydocosapentaenoic acid; EpETrE, epoxy-eicosatrienoic acid; FA, free fatty acids; HDoHE, hydroxy-docosahexaenoic acid; HETE, hydroxyeicosatetraenoic acid; HETrE, hydroxyeicosatrienoic acid; HEPE, hydroxyeicosapentaenoic acid; HHTrE, hydroxyheptadecatrienoic acid; HODE, hydroxyoctadecadienoic acid; HOTrE, hydroxy-9Z,11E,15Z-octadecatrienoic acid; KETE, oxo-eicosatetraenoic acid; KODE, oxo-octadecadienoic acid; LPC, lysophosphatidylcholine; LPC(O), plasmalogen lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; LOX, lipoxygenase; LT, leukotrine; PC, phosphatidylcholine; PC(O), plasmalogen phosphatidylcholine; PE, phosphatidylethanolamine; PE(O), plasmalogen phosphatidylethanolamine; PG, prostaglandin; SM – sphingomyelins; SN, stereospecific position; TG, triglyceride; Trail, TNF-related apoptosis-inducing ligand; TriHOME, trihydroxy-octadecenoic acid; TX, thromboxane.