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. 2017 Jul 6;216(5):554–564. doi: 10.1093/infdis/jix248

Figure 2.

Figure 2.

Relative hazard of suicidality by genotype level among participants randomly assigned to efavirenz-containing regimens. Each incremental CYP2B6/CYP2A6 genotype level (levels 1–12) is known to be associated with progressively greater plasma efavirenz exposure. The estimated relative hazard of suicidality is shown overall and within each race/ethnicity group, for both exposed and on-treatment risk periods. Overall P values test reflect the main effect of genotype level; race/ethnicity P values, a statistical interaction between genotype level and race/ethnicity group. Hazard ratios were estimated from a weighted Cox model stratified by race/ethnicity; robust Wald confidence intervals (CIs) and P values are shown.