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. 2017 Jul 6;216(5):554–564. doi: 10.1093/infdis/jix248

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© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Genotype level fit with a quadratic spline. CYP2B6/CYP2A6 genotype level was fit with a quadratic spline with 4 equally spaced knots at levels 2, 3, 4, and 6, as indicated by downward arrows. Each hash mark represents the participant’s observed genotype level (n = 1833); solid line, the estimated relative hazard; and dashed lines, pointwise 95% Wald-type confidence intervals from a weighted Cox model stratified by race/ethnicity group. This provides support for the assumption of a linear association with no apparent threshold effect. The unweighted result was similar and slightly closer to linear (data not shown).