Table 1.

Symptom Locations and Definitions of Respiratory Syncytial Virus (RSV)–Associated Acute Respiratory Illness (ARI) and Lower Respiratory Tract Illness (LRTI)

Variable	Symptom or Definition
Location
Upper respiratory tract	Nasal congestion/rhinorrhea (runny or stuffy nose), sore throat, and earache or ear pain
Lower respiratory tract	Cough, dyspnea (shortness of breath), sputum (coughing up sputum or phlegm), and wheezing by self-report
Systemic	Myalgias or arthralgias (overall body aches), fatigue (tiredness), headache, decreased appetite, and feverishness
Definition
ARI (primary end point)	Detection of RSV in at least 1 respiratory sample at the time of illness plus ≥1 symptom from any 2 of 3 locations
LRTI (secondary end point)	Detection of RSV in at least 1 respiratory sample at the time of illness plus ≥2 lower respiratory tract symptoms