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Mean cytokine levels (± standard error [SE]) in the 3 adverse event (AE) groups over time. Interleukin 6 (IL-6) (A), interleukin 10 (IL-10) (B), monocyte chemoattractant protein 1 (MCP-1) (C), and macrophage inflammatory protein 1β (MIP-1β) (D) increased posttreatment in the moderate AE group, whereas there were no significant changes in the no or mild AE groups. Significance (Kruskal–Wallis H test): * P < .05; **P < .01.
