Representative fallopian tube histological staining with hematoxylin and eosin for uninfected animals, animals with pelvic inflammatory disease (PID), and animals with lower reproductive tract infection, by levonorgestrel (LNG)–releasing intrauterine system (LNG-IUS) receipt. PID, when present, was manifested as leukocyte infiltration to the tubal propria (salpingitis). A and B, Uninfected animals without (A) and with (B) the LNG-IUS, showing high magnification of thin tubal propria lined by epithelium (inset shows the low-magnification overview). C and D, Infected animals positive for PID, showing infiltrating leukocytes (long arrows) in animals without (C) and with (D) an LNG-IUS. Leukocyte infiltration is seen as proprial thickening (short arrows) at low magnification (insets) in both animals. E and F, Infected animals with infection confined to the lower reproductive tract, showing normal thin propria (similar to uninfected controls) in animals without (E) and with (F) an LNG-IUS. See the text for a description of leukocytic infiltrations. Scale bars denote 70 um (panels) and 700 um (insets).