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. 2017 Sep 9;216(9):1063–1069. doi: 10.1093/infdis/jix470

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© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Association results of gene-based testing. Quantile–quantile plots of observed −log₁₀(P) (diamonds, y axis) vs −log₁₀(P) expected under the null hypothesis (red dashed line). Analysis was performed including all variants regardless of predicted function (A), only variants predicted to modify the protein (B), and only variants predicted to highly impact the protein structure (C). Only genes within the MHC were associated after correcting for multiple comparisons. The distribution of P values of non-MHC genes (blue diamonds) closely follows the expected null distribution.