Table 1.

Study Designs and Sample Numbers Included

Study design	Description	n cases	n controls	n total	Phenotype class	Contributors
Natural history	HIV+ patients with spVL selected from full phenotype distribution	na	na	392	quantitative	Swiss HIV Cohort Study
HIV extreme vs population	HIV elite controllers compared to a mixed sample of HIV+ and HIV negative	191 (HIV-EC)	428 (63 HIV+)	619	binary	International HIV Controllers Study, AIDS Clinical Trials Group, Autism Sequence Consortium
HIV extreme	HIV controllers compared to HIV rapid progressors	130 (HIV-C)	186 (HIV-RP)	316	binary	CASCADE, Multicenter AIDS Cohort Study, HIV Genomics Consortium

Abbreviations: HIV-EC, HIV elite controllers; HIV-C, HIV controllers; HIV-RP, HIV rapid progressors; spVL, set point viral load; na, not applicable.