Table 2.
Estimated Costs of Materials for Inactivated Polio Vaccination Per Immunized Child
| Options | IPV | Device | Cost per child immunized (USD) | |
|---|---|---|---|---|
| Delivery device | Total cost (vaccine + device) | |||
| Current strategy | Sanofi 10-dose vial (1 full dose) | IM AD needle and syringe | 0.04 | 1.1 |
| BBio 5-dose vial (1 full dose) | IM AD needle and syringe | 0.04 | 2.3 | |
| Proposed alternatives | BBio 5-dose vial (2 fractional doses) | ID AD needle and syringe | 0.08 | 1.0 |
| ID adapter | 1.1 | 2.0 | ||
| Jet injector | 1.6 | 2.5 | ||
| BBio 1-dose vial (2 fractional doses) | ID AD needle and syringe | 0.08 | 1.4 | |
| ID adapter | 1.1 | 2.4 | ||
| Jet injector | 1.7 | 3.0 | ||
Key assumptions in cost estimates include the following:
Cost of vaccine per intramuscular dose: Sanofi 10-dose vial—$0.82; BBio 5-dose vial—$1.90; BBio 1-dose vial—$2.80.
Vaccine wastage rate: Single dose vial—5%; 5-dose vial—15%; >10 dose vial—20%.
Cost of devices: Intramuscular or intradermal autodiable needle and syringe—$0.04; Intradermal adapter with autodisable syringe—$0.55; Jet injector (including a needle-free syringe, filling adapter and device)—$0.75–$0.85 per injection.
Total uses per jet injector: approximately 1000, based on preliminary calculations of potential fractional inactivated poliovirus vaccine delivery volumes for 2 years during inactivated poliovirus vaccine supply shortage. Lifespan of device is ≥20 000 uses, but this could span many years in a routine immunization setting.
Abbreviations: AD, autodisable; BBio, Bilthoven Biologicals; ID, intradermal; IM, intramuscular; IPV, inactivated poliovirus vaccine.