Figure 1.

Genetic and transcriptomic data related to the riboflavin operon in pneumococci. A, The riboflavin operon is depicted with riboflavin genes ribD, ribE, ribA, and ribH (red) and flanking genes (gray). B, RNA expression data at 5 time points (2–6 hours after initial incubation) are illustrated for each riboflavin gene and the flanking genes. Genes marked with differential expression levels in green were upregulated, and those in red were downregulated during incubation at 40°C as compared to normal incubation at 37°C. *P < .05.