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The five phases (A–E) an individual may pass through in the transition from health to the development of RA (phase F)
The open circle in phase D represents a painful but non-swollen joint. The filled shapes in phases E and F represent joints with clinically apparent soft tissue swelling. Reprinted from Raza K, Gerlag DM, Preclinical inflammatory rheumatic diseases: an overview and relevant nomenclature, Rheum Dis Clin N Am 2014;40:569–80, © 2014, with permission from Elsevier.
