Table 1.
Association analysis of rs670 and rs5128 with risk of gout using all controls
| Case genotypes, n (freq) | Control genotypes, n (freq) | Unadjusted | Adjusteda | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | T Freq | CC | CT | TT | T Freq | Allelic OR (T-Allele), (95% CI) | Allelic P | Allelic OR (T-Allele), (95% CI) | Allelic P | |
|
| ||||||||||||
| rs670 (APOA1) | ||||||||||||
| European | 1204 (0.693) | 470 (0.270) | 64 (0.037) | 598 (0.172) | 6911 (0.708) | 2629 (0.269) | 227 (0.023) | 3083 (0.158) | 1.11 (1.01, 1.22) | 0.035 | 1.11 (1.00, 1.24) | 0.055 |
| 1.07 (0.93, 1.25) | 0.34 | |||||||||||
| 1.14 (1.00, 1.30) | 0.051 | |||||||||||
| Eastern Polynesian | 356 (0.739) | 87 (0.180) | 39 (0.081) | 165 (0.171) | 487 (0.780) | 132 (0.212) | 05 (0.008) | 142 (0.114) | 1.50 (1.20, 1.88) | 0.0004 | 1.61 (1.12, 2.15) | 0.001 |
| 1.74 (1.26, 2.42) | 0.001 | |||||||||||
| 1.56 (1.16, 2.10) | 0.003 | |||||||||||
| EP/WP | 20 (0.588) | 10 (0.294) | 04 (0.118) | 18 (0.265) | 51 (0.739) | 17 (0.246) | 01 (0.015) | 19 (0.138) | 2.11 (1.04, 4.28) | 0.039 | 1.97 (0.88, 4.39) | 0.097 |
| 1.98 (0.84, 4.67) | 0.12 | |||||||||||
| 2.23 (0.91, 5.43) | 0.078 | |||||||||||
| Western Polynesian | 266 (0.670) | 121 (0.305) | 10 (0.025) | 141 (0.178) | 221 (0.742) | 71 (0.238) | 06 (0.020) | 83 (0.139) | 1.34 (1.00, 1.81) | 0.053 | 1.38 (0.97, 1.95) | 0.074 |
| 1.49 (1.01, 2.21) | 0.045 | |||||||||||
| 1.47 (1.02, 2.12) | 0.039 | |||||||||||
|
| ||||||||||||
| CC | CG | GG | G Freq | CC | CG | GG | G Freq | Allelic OR (G-Allele), (95% CI) | Allelic P | Allelic OR (G-Allele), (95% CI) | Allelic P | |
|
| ||||||||||||
| rs5128 (APOC3) | ||||||||||||
| European | 1464 (0.849) | 245 (0.142) | 16 (0.009) | 277 (0.080) | 8165 (0.833) | 1542 (0.157) | 94 (0.010) | 1730 (0.088) | 0.90 (0.79, 1.03) | 0.13 | 0.91 (0.79, 1.06) | 0.22 |
| 0.81 (0.66, 0.99) | 0.039 | |||||||||||
| 0.89 (0.75, 1.06) | 0.20 | |||||||||||
| Eastern Polynesian | 192 (0.400) | 241 (0.502) | 47 (0.098) | 335 (0.349) | 268 (0.432) | 271 (0.436) | 82 (0.132) | 435 (0.350) | 0.99 (0.83, 1.19) | 0.95 | 0.98 (0.78, 1.24) | 0.91 |
| 0.93 (0.71, 1.20) | 0.57 | |||||||||||
| 0.96 (0.76, 1.22) | 0.74 | |||||||||||
| EP/WP | 15 (0.441) | 14 (0.412) | 05 (0.147) | 24 (0.353) | 26 (0.371) | 30 (0.429) | 14 (0.200) | 58 (0.414) | 0.79 (0.45, 1.40) | 0.42 | 0.83 (0.42, 1.63) | 0.60 |
| 1.04 (0.50, 2.17) | 0.92 | |||||||||||
| 0.74 (0.37, 1.50) | 0.40 | |||||||||||
| Western Polynesian | 163 (0.405) | 177 (0.439) | 63 (0.156) | 303 (0.376) | 82 (0.275) | 157 (0.527) | 59 (0.198) | 275 (0.461) | 0.71 (0.57, 0.87) | 0.002 | 0.65 (0.50, 0.84) | 0.001 |
| 0.62 (0.46, 0.82) | 0.001 | |||||||||||
| 0.66 (0.50, 0.86) | 0.003 | |||||||||||
aTop value adjusted for age and sex; middle value adjusted for age, sex, triglyceride and HDL-C; bottom value adjusted for age, sex and BMI. Polynesian sample sets were additionally adjusted for STRUCTURE ancestry estimate. WP: Western Polynesian; EP: Eastern Polynesian. HDL-C: high-density lipoprotein cholesterol; freq: frequency.