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. 2016 Dec 30;215(5):781–785. doi: 10.1093/infdis/jiw638

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© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

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Figure 2. — Antibody-dependent enhancement (ADE) of Zika virus (ZIKV) infection by dengue antibodies. A, Longitudinal serum samples from dengue-infected patients were used to determine the kinetics of ADE of ZIKV infection after dengue exposure in individuals experiencing a primary (dotted lines) or secondary (solid lines) dengue infection. Antibody-dependent enhancement of dengue virus (DENV) (B) and ZIKV (C) was tested in the presence of a panel of serum samples from pregnant women with different dengue immune status, as determined by plaque reduction neutralization test: monotypic (DENV-3) (n = 10) and multitypic (DENV-3 and DENV-4) (n = 10). C, The n-fold increase in the ZIKV RNA quantification in the presence of monotypic or multitypic dengue immune serum relative to that in a Flavivirus-naive serum. Abbreviations: ADE, Antibody-dependent enhancement; DENV, dengue virus; ZIKV, Zika virus, vRNA, virus ribonucleic acid.